Cox-2 Inhibitors Linked to Cardiovascular Issues
You have probably seen or read about Cox inhibitors in the news recently. All Cox inhibitors are part of a class of drugs called non-steroidal anti-inflammatory drugs (NSAID). While successful for millions of Americans in reducing pain, certain NSAIDs have long been associated with serious cardiovascular problems.
NSAIDs work by inhibiting proteins called cyclo-oxygenase 1 and 2 (Cox 1 & Cox 2). By inhibiting these proteins, pain and inflammation in the body is suppressed. NSAIDs that focus on the Cox-2 protein have the pain relieving effects without the gastrointestinal side effects associated with the less specific NSAIDs (e.g. aspirin, Tylenol).
Studies indicate that the more a NSAID focuses on the Cox-2 protein, the greater the risk of serious cardiovascular problems. Vioxx, Celebrex, and Bextra all focus on the Cox-2 protein. Other drugs, such as Naproxen, inhibit Cox-2 also, but are less specific than Vioxx and Celebrex.
The dangers of these drugs are very real, as evidenced by the withdrawal of Vioxx, and the recent halt of studies involving Celebrex and Naproxen. In fact, the health regulatory body in England recently instructed doctors to switch all patients off Cox-2 inhibitors. It is appalling that our own health regulatory body, the FDA, does not warn US citizens of the dangers of Cox-2 inhibitors.
If you or a loved one have taken a Cox-2 inhibitor such as Vioxx, Celebrex, or Bextra, and suffered a heart attack, stroke, or serious blood clotting event, call our office and contact us to discuss your legal rights.